Some people with Ph+ CML in chronic phase develop a gene mutation known as T315I. This mutation can cause resistance to some medications.
Only your doctor can determine if you have the T315I mutation through a specific test. If it turns out that you have the T315I mutation, SCEMBLIX may be right for you.
Who is SCEMBLIX for?
SCEMBLIX is a prescription medicine used to treat adults with:
- Philadelphia chromosome–positive chronic myeloid leukemia (Ph+ CML) in chronic phase (CP) with the T315I mutation
- Ph+ CML in CP with the T315I mutation
It is not known if SCEMBLIX is safe and effective in children.
How will your doctor determine whether you have the T315I mutation?
To find out if you have the T315I mutation, your doctor will need to order a test called the BCR-ABL1 kinase domain mutation analysis. This test can identify mutations in the BCR-ABL1 gene that may cause you to become resistant to certain medications that treat Ph+ CML in chronic phase.
Your doctor may decide to have you tested for a gene mutation if you are:
- Not responding or no longer responding to a medication
- Unable to reach a certain treatment milestone
Learn more about gene mutations.
Common side effects of SCEMBLIX
The most common side effects of SCEMBLIX include:
- nose, throat, or sinus (upper respiratory tract) infections
- muscle, bone, or joint pain
- decreased blood platelet counts, white blood cell counts, and red blood cell counts
- increased blood fat (triglycerides) levels
- increased blood creatine kinase levels
- increased blood liver enzyme levels
- increased blood pancreas enzyme (amylase and lipase) levels
- increased blood uric acid levels
Your doctor may change your dose, temporarily stop, or permanently stop treatment with SCEMBLIX if you have certain side effects.
SCEMBLIX may cause fertility problems in females. This may affect your ability to have a child. Talk to your doctor if this is a concern for you.
Review the serious and most common side effects of SCEMBLIX here.
Take SCEMBLIX exactly as prescribed
If your doctor prescribes SCEMBLIX because you have Ph+ CML in chronic phase with the T315I mutation, take the medication exactly as instructed.
Your doctor will have you take SCEMBLIX twice a day 12 hours apart. Do not eat for at least 2 hours before taking SCEMBLIX and 1 hour after your dose. Learn more about taking SCEMBLIX.