SCEMBLIX® (asciminib) tablets is a prescription medicine used to treat adults with:
- Philadelphia chromosome–positive chronic myeloid leukemia (Ph+ CML) in chronic phase (CP), previously treated with 2 or more tyrosine kinase inhibitors (TKIs)
- The effectiveness of SCEMBLIX in patients previously treated with 2 or more TKIs is based on a study that measured major molecular response (MMR) rates. No clinical information is available to show if these patients treated with SCEMBLIX live longer or if their symptoms improve. Ongoing studies exist to find out how SCEMBLIX works over a longer period of time.
It is not known if SCEMBLIX is safe and effective in children.
Some patients struggle with drug resistance or unmanageable side effects
For some people, the journey with Ph+ CML in chronic phase can have its ups and downs. That can be for a number of reasons:
- Your body does not respond to a medication, which is known as primary drug resistance
- Your body stops responding to a medication, referred to as secondary drug resistance
- Side effects become unmanageable, which can make it difficult to stay on track with your treatment
Don’t keep concerns to yourself
If you’re not seeing the results you had expected from your current medication, it’s important to speak up.
You may want to talk with your doctor to see if SCEMBLIX may be right for you. A good way to get the conversation started is by using this Doctor Discussion Guide.
How SCEMBLIX works
SCEMBLIX is the first and only TKI that is thought to bind to a different site within the gene that causes Ph+ CML in chronic phase. Your doctor may refer to this as the myristoyl pocket.
Talk with your doctor about SCEMBLIX
When you have Ph+ CML in chronic phase, it’s important to be your own advocate. To help you have a productive conversation, download the Doctor Discussion Guide.
Common side effects of SCEMBLIX
The most common side effects of SCEMBLIX include:
- nose, throat, or sinus (upper respiratory tract) infections
- muscle, bone, or joint pain
- decreased blood platelet counts, white blood cell counts, and red blood cell counts
- increased blood fat (triglycerides) levels
- increased blood creatine kinase levels
- increased blood liver enzyme levels
- increased blood pancreas enzyme (amylase and lipase) levels
Your doctor may change your dose, temporarily stop, or permanently stop treatment with SCEMBLIX if you have certain side effects.
SCEMBLIX may cause fertility problems in females. This may affect your ability to have a child. Talk to your doctor if this is a concern for you.
Be sure to review information about the serious and most common side effects of SCEMBLIX. Learn more
How to take SCEMBLIX
If your doctor prescribes SCEMBLIX after you have been treated with 2 prior TKIs, be sure to take the medication exactly as instructed.
Do not eat for at least 2 hours before taking SCEMBLIX and 1 hour after your dose. Learn more about taking SCEMBLIX.